| Gene Information | |
|---|---|
| Gene Name | AP1G2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 785 |
| Protein Names | AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000213983 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75843 |
| Gene Card | AP1G2 |
| Uniprot ID | O75843 |
| Pfam | PF01602; PF02883 |
| In ASD | no |
| Allosteric Prediction | no (-1.376004204) |
| Ortholog in Animals | Alpaca_ AP1G2 ( ortholog_one2one ) Dog_ AP1G2 ( ortholog_one2one ) GuineaPig_ AP1G2 ( ortholog_one2one ) Macaque_ AP1G2 ( ortholog_one2one ) Mouse_ Ap1g2 ( ortholog_one2one ) Pig_ AP1G2 ( ortholog_one2one ) Rat_ Ap1g2 ( ortholog_one2one ) Rabbit_ AP1G2 ( ortholog_one2one ) |
| Ohnologs | AP1G1 |
| Paralogs | AP1G1, AP2A1, AP2A2, AP4E1 |
| Tissue | NA |
| Tissue Specificity | Expressed in all but one (skeletal muscle) tissues examined. |
| Pharmacological Animal Models | 0.025380(Chimpanzee);0.017317(Mouse);0.002419(Rat);0.013333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2E9G (NMR - ) 2YMT (X-ray 1.80A ) 3ZHF (X-ray 1.70A ) 4BCX (X-ray 2.00A ) |
| DBSNP | rs12897422 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:11333915, ECO:0000269|PubMed:9762922}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:11333915}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9733768}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:16867982}; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915). |
| Mouse PG classification | NA |
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