Gene Information
Gene NameZNF268
OrganismHomo sapiens (Human)
Gene Length947
Protein NamesZinc finger protein 268 (Zinc finger protein HZF3)
Target NameNA
Target TypeNA
Gene Age86 ( ENSG00000090612 )
Evolutionary StageMammalia
AlphaFoldDBQ14587
Gene CardZNF268
Uniprot IDQ14587
PfamPF01352; PF00096
In ASDno
Allosteric Predictionno (-0.982225313)
Ortholog in AnimalsAlpaca_ ZNF268 ( ortholog_one2one )
Dog_ ZNF268 ( ortholog_one2one )
Macaque_ ZNF268 ( ortholog_one2one )
Pig_ ZNF268 ( ortholog_one2one )
OhnologsZNF286A, ZNF3
ParalogsZNF45, ZNF775, ZNF140, ZNF544, ZNF841, ZNF7, ZNF571, ZNF28, GLI4, ZNF732, ZNF595, ZNF718, ZNF493, ZNF117, ZNF141, ZNF607, ZNF484, ZFP3, ZNF790, ZNF540, ZNF286A, ZNF672, ZNF629, ZNF605, ZNF836, ZNF483, ZNF71, ZNF713, MZF1, ZNF460, ZNF517, ZNF585A, ZNF585B, ZNF157, ZNF16, ZNF621, ZNF221, ZNF224, ZNF225, ZNF284, ZNF354B, ZNF615, ZNF471, ZNF677, ZNF502, ZSCAN10, ZNF490, ZNF658, ZNF568, ZNF624, ZNF432, ZNF30, ZNF623, ZNF260, ZNF93, ZNF138, ZNF676, ZNF735, ZNF722, ZNF254, ZNF492, ZNF726, ZNF679, ZNF90, ZNF708, ZNF716, ZNF714, ZNF728, ZNF486, ZNF506, ZNF300, ZNF132, ZIM2, ZNF696, ZNF317, ZNF616, ZFP14, ZNF275, ZNF32, ZNF534, ZFP1, ZNF780A, ZNF182, ZNF234, ZNF782, ZFP28, ZIM3, ZKSCAN5, ZNF415, ZNF573, ZFP2, ZNF189, ZNF519, ZNF195, ZNF429, ZFP30, ZNF699, ZNF630, ZNF829, ZNF383, ZNF43, ZNF655, ZNF543, ZNF227, ZNF345, ZNF354A, ZNF37A, ZNF454, ZNF780B, ZNF267, ZNF814, ZNF2, ZNF226, ZNF546, ZNF331, ZNF283, ZNF628, ZNF565, ZNF879, ZNF74, ZNF311, ZNF501, ZNF3, ZKSCAN8P1, ZNF135, ZNF391, ZNF510, ZNF470, ZNF606, ZNF239, ZNF23, ZNF320, ZFP82, ZNF235, ZNF146, ZNF251, ZNF322, ZNF514, ZNF461, ZNF600, ZNF611, ZNF26, ZNF121, ZNF33A, ZNF33B, ZNF334, ZNF250, ZNF197, ZNF577, ZNF436, ZNF835, ZNF112, ZNF229, ZNF81, ZNF789, ZNF724, ZNF695, ZNF681, ZNF682, ZNF727, ZNF678, ZNF736, ZNF738, ZNF85, ZNF175, ZNF354C, ZNF41, ZNF717, ZNF528, ZNF880, ZNF83, RBAK, ZNF12
TissueNA
Tissue SpecificityOverexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. {ECO:0000269|PubMed:12200376, ECO:0000269|PubMed:16735226, ECO:0000269|PubMed:16865230, ECO:0000269|PubMed:18949428, ECO:0000269|PubMed:23091055, ECO:0000269|PubMed:23946776}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2EL4  (NMR  -  )  2EL5  (NMR  -  )  2EL6  (NMR  -  )  2EM1  (NMR  -  )  2EMV  (NMR  -  )  2EMW  (NMR  -  )  2EMX  (NMR  -  )  2EMY  (NMR  -  )  2EN0  (NMR  -  )  2EN6  (NMR  -  )  2EN7  (NMR  -  )  2EOF  (NMR  -  )  2EOG  (NMR  -  )  2EOI  (NMR  -  )  2EOJ  (NMR  -  )  2EOK  (NMR  -  )  2EOL  (NMR  -  )  2EOP  (NMR  -  )  2EPV  (NMR  -  )  2EPW  (NMR  -  )  2EPY  (NMR  -  )  2YTF  (NMR  -  )  2YTQ  (NMR  -  ) 
DBSNP rs7975069 
Subcellular location [CC][Isoform 1]: Nucleus {ECO:0000269|PubMed:23665872}.;
[Isoform 2]: Nucleus {ECO:0000269|PubMed:23665872}. Cytoplasm {ECO:0000269|PubMed:23665872}.
Mouse PG classificationNA
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