| Gene Information | |
|---|---|
| Gene Name | MAP1LC3C |
| Organism | Homo sapiens (Human) |
| Gene Length | 147 |
| Protein Names | Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000197769 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BXW4 |
| Gene Card | MAP1LC3C |
| Uniprot ID | Q9BXW4 |
| Pfam | PF02991 |
| In ASD | no |
| Allosteric Prediction | no (-0.786251254) |
| Ortholog in Animals | Alpaca_ MAP1LC3C ( ortholog_one2one ) Dog_ MAP1LC3C ( ortholog_one2one ) Pig_ MAP1LC3C ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GABARAPL1, GABARAP, MAP1LC3A, GABARAPL2, MAP1LC3B2, MAP1LC3B |
| Tissue | adipose.tissue, lung |
| Tissue Specificity | Most abundant in placenta, lung and ovary. {ECO:0000269|PubMed:12740394}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NCN (NMR - ) 3VVW (X-ray 2.50A ) 3WAM (X-ray 1.75A ) 3WAP (X-ray 3.10A ) 5DPW (X-ray 2.19A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12740394, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:23459205, ECO:0000269|PubMed:31709703}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12740394}. Note=LC3-II binds to the autophagic membranes. {ECO:0000269|PubMed:12740394}. |
| Mouse PG classification | NA |
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