| Gene Information | |
|---|---|
| Gene Name | SI |
| Organism | Homo sapiens (Human) |
| Gene Length | 1827 |
| Protein Names | Sucrase-isomaltase, intestinal [Cleaved into: Sucrase (EC 3.2.1.48); Isomaltase (EC 3.2.1.10)] |
| Target Name | sucrase-isomaltase, intestinal |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000090402 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P14410 |
| Gene Card | SI |
| Uniprot ID | P14410 |
| Pfam | PF01055; PF16863; PF00088 |
| In ASD | no |
| Allosteric Prediction | yes (0.69641034) |
| Ortholog in Animals | Alpaca_ SI ( ortholog_one2one ) GuineaPig_ SI ( ortholog_one2one ) Macaque_ SI ( ortholog_one2one ) Mouse_ Sis ( ortholog_one2one ) Pig_ SI ( ortholog_one2one ) Rat_ Si ( ortholog_one2one ) Rabbit_ SI ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MYORG, GANC, MGAM2, GAA, GANAB, MGAM |
| Tissue | duodenum, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. {ECO:0000269|PubMed:1677636}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3LPO (X-ray 3.20A ) 3LPP (X-ray 2.15A ) |
| DBSNP | rs9290264 rs121912612 rs9283633 rs267607049 rs121912615 rs765433197 rs121912613 rs121912616 rs121912611 rs121912614 rs143388292 rs4855271 rs79717168 rs9917722 |
| Subcellular location [CC] | Apical cell membrane; Single-pass type II membrane protein. Note=Brush border. |
| Mouse PG classification | NA |
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