| Gene Information | |
|---|---|
| Gene Name | TNC |
| Organism | Homo sapiens (Human) |
| Gene Length | 2201 |
| Protein Names | Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C) |
| Target Name | tenascin |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000041982 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P24821 |
| Gene Card | TNC |
| Uniprot ID | P24821 |
| Pfam | PF07974; PF18720; PF00147; PF00041 |
| In ASD | no |
| Allosteric Prediction | no (-0.365697249) |
| Ortholog in Animals | Alpaca_ TNC ( ortholog_one2one ) Dog_ TNC ( ortholog_one2one ) GuineaPig_ TNC ( ortholog_one2one ) Macaque_ TNC ( ortholog_one2one ) Mouse_ Tnc ( ortholog_one2one ) Pig_ TNC ( ortholog_one2one ) Rat_ Tnc ( ortholog_one2one ) Rabbit_ TNC ( ortholog_one2one ) |
| Ohnologs | TNR, TNN |
| Paralogs | FCN1, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, TNN, ANGPTL6, TNXB, FGB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, FGA, ANGPTL2, ANGPTL7, FCN3, FNDC7, FGL2, FGG, ANGPT1, FN1, ANGPT2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1TEN (X-ray 1.80A ) 2RB8 (X-ray 1.45A ) 2RBL (X-ray 2.10A ) 5R5T (X-ray 1.55A ) 5R5U (X-ray 1.52A ) 5R5V (X-ray 1.70A ) 5R5W (X-ray 1.60A ) 5R5X (X-ray 1.56A ) 5R5Y (X-ray 1.57A ) 5R5Z (X-ray 1.67A ) 5R60 (X-ray 1.79A ) 5R61 (X-ray 1.38A ) 5R62 (X-ray 1.40A ) 5R63 (X-ray 1.59A ) 6BRB (X-ray 2.82A ) 6QNV (X-ray 1.40A ) |
| DBSNP | rs7020958 rs1757095 rs3827816 rs1061494 rs3748169 rs2104772 rs137933052 rs2274750 rs431905513 rs13321 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix. |
| Mouse PG classification | NA |
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