| Gene Information | |
|---|---|
| Gene Name | ATP13A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1196 |
| Protein Names | Probable cation-transporting ATPase 13A4 (EC 7.2.2.-) (P5-ATPase isoform 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000127249 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q4VNC1 |
| Gene Card | ATP13A4 |
| Uniprot ID | Q4VNC1 |
| Pfam | PF00690; PF12409 |
| In ASD | no |
| Allosteric Prediction | no (-0.761644804) |
| Ortholog in Animals | Alpaca_ ATP13A4 ( ortholog_one2one ) GuineaPig_ ATP13A4 ( ortholog_one2one ) Macaque_ ATP13A4 ( ortholog_one2one ) Mouse_ Atp13a4 ( ortholog_one2one ) Pig_ ATP13A4 ( ortholog_one2one ) Rat_ Atp13a4 ( ortholog_one2one ) |
| Ohnologs | ATP13A2 |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP7B, ATP13A5, ATP12A, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | thyroid |
| Tissue Specificity | Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen (PubMed:15925480). Highly expressed in the respiratory and integumentary systems (PubMed:29505581). {ECO:0000269|PubMed:15925480, ECO:0000269|PubMed:29505581}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs6788448 rs35424709 |
| Subcellular location [CC] | Early endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q5XF90}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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