Gene Information
Gene NameTRARG1
OrganismHomo sapiens (Human)
Gene Length177
Protein NamesTrafficking regulator of GLUT4 1 (Dispanin subfamily B member 1) (DSPB1) (Interferon-induced transmembrane domain-containing protein D3) (Protein located at seventeen-p-thirteen point three 1) (Tumor suppressor candidate 5)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000184811 )
Evolutionary StageVertebrata
AlphaFoldDBQ8IXB3
Gene CardTRARG1
Uniprot IDQ8IXB3
PfamPF04505
In ASDno
Allosteric Predictionno (-1.408591097)
Ortholog in AnimalsAlpaca_ TRARG1 ( ortholog_one2one )
GuineaPig_ TRARG1 ( ortholog_one2one )
Macaque_ TRARG1 ( ortholog_one2one )
Mouse_ Trarg1 ( ortholog_one2one )
Pig_ TRARG1 ( ortholog_one2one )
Rat_ Trarg1 ( ortholog_one2one )
Rabbit_ TRARG1 ( ortholog_one2one )
OhnologsNA
ParalogsPRRT1, PRRT1B, TMEM233, PRRT2
Tissueadipose.tissue, bone.marrow, breast, greater.omentum, subcutaneous.adipose.tissue
Tissue SpecificityExpressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404). {ECO:0000269|PubMed:12660825, ECO:0000269|PubMed:26629404}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs75616699  rs111587833  rs111701043  rs6502774  rs75025906  rs6502776 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:Q8C838};
Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838}. Endomembrane system {ECO:0000250|UniProtKB:Q8C838};
Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8C838}. Note=Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. {ECO:0000250|UniProtKB:Q8C838}.
Mouse PG classificationNA
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