| Gene Information | |
|---|---|
| Gene Name | FADS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2) |
| Target Name | fatty acid desaturase 2 |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000134824 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O95864 |
| Gene Card | FADS2 |
| Uniprot ID | O95864 |
| Pfam | PF00173; PF00487 |
| In ASD | no |
| Allosteric Prediction | yes (0.461638718) |
| Ortholog in Animals | Alpaca_ FADS2 ( ortholog_one2one ) Dog_ FADS2 ( ortholog_one2one ) GuineaPig_ FADS2 ( ortholog_one2one ) Macaque_ FADS2 ( ortholog_one2one ) Mouse_ Fads2 ( ortholog_one2one ) Pig_ FADS2 ( ortholog_one2one ) Rat_ Fads2 ( ortholog_one2one ) Rabbit_ FADS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FADS3, FADS1, FADS6 |
| Tissue | adrenal.gland |
| Tissue Specificity | Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index. {ECO:0000269|PubMed:10860662, ECO:0000269|PubMed:12851727, ECO:0000269|PubMed:9867867}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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