| Gene Information | |
|---|---|
| Gene Name | RAPGEF6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1601 |
| Protein Names | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000158987 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8TEU7 |
| Gene Card | RAPGEF6 |
| Uniprot ID | Q8TEU7 |
| Pfam | PF00027; PF00595; PF00788; PF00617; PF00618 |
| In ASD | no |
| Allosteric Prediction | no (-0.781599765) |
| Ortholog in Animals | Alpaca_ RAPGEF6 ( ortholog_one2one ) Dog_ RAPGEF6 ( ortholog_one2one ) GuineaPig_ RAPGEF6 ( ortholog_one2one ) Macaque_ RAPGEF6 ( ortholog_one2one ) Mouse_ Rapgef6 ( ortholog_one2one ) Pig_ RAPGEF6 ( ortholog_one2one ) Rat_ Rapgef6 ( ortholog_one2one ) Rabbit_ RAPGEF6 ( ortholog_one2one ) |
| Ohnologs | RAPGEF2 |
| Paralogs | RALGDS, RASGEF1A, RASGRF2, RASGRP3, SOS2, RAPGEF3, RASGRF1, RAPGEF2, RGL1, RAPGEF1, RASGEF1B, RASGRP2, RGL2, SOS1, RGL3, RALGPS1, RALGPS2, RAPGEF4, RGL4, RASGRP4, RAPGEFL1, RAPGEF5, RASGRP1, RASGEF1C |
| Tissue | NA |
| Tissue Specificity | Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524421}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2D93 (NMR - ) 3LNY (X-ray 1.30A ) |
| DBSNP | rs3756293 rs34112735 rs7717835 rs1291602 rs1064539 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane. |
| Mouse PG classification | NA |
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