| Gene Information | |
|---|---|
| Gene Name | MVD |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) |
| Target Name | diphosphomevalonate decarboxylase |
| Target Type | Literature-reported target |
| Gene Age | 3 ( ENSG00000167508 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | P53602 |
| Gene Card | MVD |
| Uniprot ID | P53602 |
| Pfam | PF00288; PF18376 |
| In ASD | no |
| Allosteric Prediction | no (-0.079200162) |
| Ortholog in Animals | Alpaca_ MVD ( ortholog_one2one ) Dog_ MVD ( ortholog_one2one ) GuineaPig_ MVD ( ortholog_one2one ) Macaque_ MVD ( ortholog_one2one ) Mouse_ Mvd ( ortholog_one2one ) Pig_ MVD ( ortholog_one2one ) Rat_ Mvd ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta. {ECO:0000269|PubMed:8626466}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3D4J (X-ray 2.40A ) |
| DBSNP | rs200033380 rs776358937 rs144010349 rs770939767 rs776684503 rs761991070 rs34519538 rs755948940 rs764836183 rs546127665 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14972328}. |
| Mouse PG classification | NA |
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