Gene Information
Gene NameMAPK8IP3
OrganismHomo sapiens (Human)
Gene Length1336
Protein NamesC-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000138834 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9UPT6
Gene CardMAPK8IP3
Uniprot IDQ9UPT6
PfamPF16471; PF09744
In ASDno
Allosteric Predictionno (-0.143830299)
Ortholog in AnimalsAlpaca_ MAPK8IP3 ( ortholog_one2one )
Dog_ MAPK8IP3 ( ortholog_one2one )
GuineaPig_ MAPK8IP3 ( ortholog_one2one )
Macaque_ MAPK8IP3 ( ortholog_one2one )
Mouse_ Mapk8ip3 ( ortholog_one2one )
Pig_ MAPK8IP3 ( ortholog_one2one )
Rat_ Mapk8ip3 ( ortholog_one2one )
OhnologsSPAG9
ParalogsSPAG9
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4PXJ  (X-ray  2.06A  ) 
DBSNP rs1596711175  rs1567198751  rs1596780112  rs1567203083  rs2294619  rs1163583945  rs1567214097 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:Q9ESN9}. Golgi apparatus {ECO:0000250|UniProtKB:Q9ESN9}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9ESN9}. Cell projection, axon {ECO:0000250|UniProtKB:E9PSK7}. Cell projection, dendrite {ECO:0000250|UniProtKB:E9PSK7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:E9PSK7}. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation. {ECO:0000250|UniProtKB:E9PSK7, ECO:0000250|UniProtKB:Q9ESN9}.
Mouse PG classificationNA
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