| Gene Information | |
|---|---|
| Gene Name | TCN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 433 |
| Protein Names | Transcobalamin-1 (TC-1) (Haptocorrin) (HC) (Protein R) (Transcobalamin I) (TC I) (TCI) |
| Target Name | transcobalamin-1 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000134827 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20061 |
| Gene Card | TCN1 |
| Uniprot ID | P20061 |
| Pfam | PF01122; PF14478 |
| In ASD | no |
| Allosteric Prediction | yes (0.222153926) |
| Ortholog in Animals | Alpaca_ TCN1 ( ortholog_one2one ) Dog_ TCN1 ( ortholog_one2one ) Macaque_ TCN1 ( ortholog_one2one ) Pig_ TCN1 ( ortholog_one2one ) Rabbit_ TCN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CBLIF, TCN2 |
| Tissue | salivary.gland, submandibular.gland, minor.salivary.gland |
| Tissue Specificity | Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils. {ECO:0000269|PubMed:2777761}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 4KKI (X-ray 2.35A ) 4KKJ (X-ray 3.00A ) |
| DBSNP | rs34528912 rs34324219 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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