| Gene Information | |
|---|---|
| Gene Name | PPP2R5C |
| Organism | Homo sapiens (Human) |
| Gene Length | 524 |
| Protein Names | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) |
| Target Name | serine/threonine-protein phosphatase 2a 56 kda regulatory subunit gamma isoform |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000078304 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13362 |
| Gene Card | PPP2R5C |
| Uniprot ID | Q13362 |
| Pfam | PF01603 |
| In ASD | no |
| Allosteric Prediction | yes (0.620930432) |
| Ortholog in Animals | Alpaca_ PPP2R5C ( ortholog_one2one ) Dog_ PPP2R5C ( ortholog_one2one ) GuineaPig_ PPP2R5C ( ortholog_one2one ) Macaque_ PPP2R5C ( ortholog_one2one ) Mouse_ Ppp2r5c ( ortholog_one2one ) Pig_ PPP2R5C ( ortholog_one2one ) Rat_ Ppp2r5c ( ortholog_one2one ) Rabbit_ PPP2R5C ( ortholog_one2one ) |
| Ohnologs | PPP2R5D |
| Paralogs | PPP2R5D, PPP2R5A, PPP2R5B, PPP2R5E |
| Tissue | NA |
| Tissue Specificity | Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2IAE (X-ray 3.50A ) 2JAK (X-ray 2.60A ) 2NPP (X-ray 3.30A ) 2NYL (X-ray 3.80A ) 2NYM (X-ray 3.60A ) 3FGA (X-ray 2.70A ) 5JJA (X-ray 2.35A ) 5K6S (X-ray 2.79A ) 5SW9 (X-ray 2.85A ) 5SWF (X-ray 2.82A ) 6OYL (X-ray 3.15A ) 6TOQ (X-ray 3.16A ) 6VOY (EM 3.70A ) 6VRO (X-ray 2.45A ) 7OUF (EM 3.00A ) 7OUG (EM 3.10A ) 7OUH (EM 3.50A ) 7PEL (EM 3.34A ) 7SOY (EM 3.40A ) |
| DBSNP | rs3742424 |
| Subcellular location [CC] | Nucleus. Chromosome, centromere. |
| Mouse PG classification | NA |
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