Gene Information
Gene NameRNF135
OrganismHomo sapiens (Human)
Gene Length432
Protein NamesE3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
Target NameNA
Target TypeNA
Gene Age132 ( ENSG00000181481 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ8IUD6
Gene CardRNF135
Uniprot IDQ8IUD6
PfamPF00622
In ASDno
Allosteric Predictionno (-0.938499118)
Ortholog in AnimalsAlpaca_ RNF135 ( ortholog_one2one )
Dog_ RNF135 ( ortholog_one2one )
GuineaPig_ RNF135 ( ortholog_one2one )
Macaque_ RNF135 ( ortholog_one2one )
Pig_ RNF135 ( ortholog_one2one )
OhnologsNA
ParalogsRFPL4B, CD80, RFPL2, RFPL3, RFPL1, CD86, RNF152, RFPL4AL1, RFPL4A, SPRYD4, PDCD1LG2, CD274
TissueNA
Tissue SpecificityExpressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Also weakly expressed in heart, thymus, liver and lung. {ECO:0000269|PubMed:19017631}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7JL1  (EM  3.90A  7JL3  (EM  4.20A 
DBSNP rs7225888  rs7211440  rs111902263  rs121918162  rs61749868 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:19484123, ECO:0000269|PubMed:23950712}. Cytoplasm, Stress granule {ECO:0000269|PubMed:23950712}.
Mouse PG classificationNA
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