| Gene Information | |
|---|---|
| Gene Name | TCF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 619 |
| Protein Names | Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000196628 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NQB0 |
| Gene Card | TCF7L2 |
| Uniprot ID | Q9NQB0 |
| Pfam | PF08347; PF00505 |
| In ASD | no |
| Allosteric Prediction | no (-0.563446468) |
| Ortholog in Animals | Alpaca_ TCF4 ( ortholog_one2one ) Dog_ TCF4 ( ortholog_one2one ) GuineaPig_ TCF4 ( ortholog_one2one ) Macaque_ TCF4 ( ortholog_one2one ) Mouse_ Tcf4 ( ortholog_one2one ) Pig_ TCF4 ( ortholog_one2one ) Rat_ Tcf4 ( ortholog_one2many ) Rabbit_ TCF4 ( ortholog_one2one ) |
| Ohnologs | TCF3, TCF12 |
| Paralogs | TCF3, TCF12 |
| Tissue | NA |
| Tissue Specificity | Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom. {ECO:0000269|PubMed:9916915}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JDH (X-ray 1.90A ) 1JPW (X-ray 2.50A ) 2GL7 (X-ray 2.60A ) |
| DBSNP | rs2757884 |
| Subcellular location [CC] | Nucleus, PML body {ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:22699938, ECO:0000269|PubMed:9916915}. Nucleus {ECO:0000269|PubMed:19304756}. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies. |
| Mouse PG classification | NA |
| click here to return to the previous page | |