Gene Information
Gene NameEFNB1
OrganismHomo sapiens (Human)
Gene Length346
Protein NamesEphrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]
Target NameNA
Target TypeNA
Gene Age886 ( ENSG00000090776 )
Evolutionary StageEumetazoa
AlphaFoldDBP98172
Gene CardEFNB1
Uniprot IDP98172
PfamPF00812
In ASDno
Allosteric Predictionno (-0.082533506)
Ortholog in AnimalsAlpaca_ EFNB1 ( ortholog_one2one )
GuineaPig_ EFNB1 ( ortholog_one2one )
Macaque_ EFNB1 ( ortholog_one2one )
Mouse_ Efnb1 ( ortholog_one2one )
Pig_ EFNB1 ( ortholog_one2one )
Rat_ Efnb1 ( ortholog_one2one )
Rabbit_ EFNB1 ( ortholog_one2one )
OhnologsEFNB3, EFNB2
ParalogsEFNB2, EFNA2, EFNB3, EFNA1, EFNA3, EFNA4, EFNA5
TissueNA
Tissue SpecificityWidely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638). {ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}.
Pharmacological Animal ModelsNULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6THG  (X-ray  4.07A  ) 
DBSNP rs104894801  rs104894796  rs2080471329  rs28936069  rs28936070  rs146636295  rs28935170  rs28936071  rs7889678  rs16989105 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10197531, ECO:0000269|PubMed:7973638};
Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:10197531}. Note=May recruit GRIP1 and GRIP2 to membrane raft domains. {ECO:0000269|PubMed:10197531}.;
[Ephrin-B1 C-terminal fragment]: Cell membrane {ECO:0000269|PubMed:16930449};
Single-pass type I membrane protein {ECO:0000305}.;
[Ephrin-B1 intracellular domain]: Nucleus {ECO:0000269|PubMed:16930449}. Note=Colocalizes with ZHX2 in the nucleus. {ECO:0000250|UniProtKB:P52795}.
Mouse PG classificationHPG
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