| Gene Information | |
|---|---|
| Gene Name | CHKA |
| Organism | Homo sapiens (Human) |
| Gene Length | 457 |
| Protein Names | Choline kinase alpha (CK) (EC 2.7.1.32) (CHETK-alpha) (Ethanolamine kinase) (EK) (EC 2.7.1.82) |
| Target Name | choline kinase |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000110721 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P35790 |
| Gene Card | CHKA |
| Uniprot ID | P35790 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | yes (1.000176716) |
| Ortholog in Animals | Alpaca_ CHKA ( ortholog_one2one ) Dog_ CHKA ( ortholog_one2one ) GuineaPig_ CHKA ( ortholog_one2one ) Macaque_ CHKA ( ortholog_one2one ) Mouse_ Chka ( ortholog_one2one ) Pig_ CHKA ( ortholog_one2one ) Rat_ Chka ( ortholog_one2one ) |
| Ohnologs | CHKB |
| Paralogs | CHKB, ETNK1, ETNK2 |
| Tissue | testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CKO (X-ray 2.15A ) 2CKP (X-ray 3.10A ) 2CKQ (X-ray 2.40A ) 2I7Q (X-ray 1.90A ) 3F2R (X-ray 2.35A ) 3G15 (X-ray 1.70A ) 3ZM9 (X-ray 1.90A ) 4BR3 (X-ray 2.20A ) 4CG8 (X-ray 1.75A ) 4CG9 (X-ray 1.83A ) 4CGA (X-ray 1.74A ) 4DA5 (X-ray 2.40A ) 5AFV (X-ray 2.25A ) 5EQE (X-ray 2.40A ) 5EQP (X-ray 2.35A ) 5EQY (X-ray 2.50A ) 5FTG (X-ray 1.45A ) 5FUT (X-ray 1.60A ) 5W6O (X-ray 2.35A ) 7A04 (X-ray 2.15A ) 7A06 (X-ray 1.80A ) 7NB1 (X-ray 2.30A ) 7NB2 (X-ray 2.40A ) 7NB3 (X-ray 2.00A ) |
| DBSNP | rs17853641 rs17853642 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:34077757}.; [Isoform 1]: Lipid droplet {ECO:0000269|PubMed:34077757}. Note=Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. {ECO:0000269|PubMed:34077757}. |
| Mouse PG classification | NA |
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