| Gene Information | |
|---|---|
| Gene Name | TDO2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase) |
| Target Name | tryptophan 2,3-dioxygenase |
| Target Type | Clinical trial target |
| Gene Age | 886 ( ENSG00000151790 ) 3 ( ENSG00000262635 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48775 |
| Gene Card | TDO2 |
| Uniprot ID | P48775 |
| Pfam | PF03301 |
| In ASD | no |
| Allosteric Prediction | yes (0.464772847) |
| Ortholog in Animals | Alpaca_ TDO2 ( ortholog_one2one ) Dog_ TDO2 ( ortholog_one2one ) GuineaPig_ TDO2 ( ortholog_one2one ) Macaque_ TDO2 ( ortholog_one2one ) Mouse_ Tdo2 ( ortholog_one2one ) Pig_ TDO2 ( ortholog_one2one ) Rat_ Tdo2 ( ortholog_one2one ) Rabbit_ TDO2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | liver, bone.marrow, pituitary.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4PW8 (X-ray 2.90A ) 5TI9 (X-ray 2.50A ) 5TIA (X-ray 2.44A ) 6A4I (X-ray 2.65A ) 6PYY (X-ray 2.40A ) 6PYZ (X-ray 2.02A ) 6UD5 (X-ray 2.05A ) 6VBN (X-ray 3.18A ) 7LU7 (X-ray 2.30A ) |
| DBSNP | rs1553957997 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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