| Gene Information | |
|---|---|
| Gene Name | TSLP |
| Organism | Homo sapiens (Human) |
| Gene Length | 159 |
| Protein Names | Thymic stromal lymphopoietin |
| Target Name | thymic stromal lymphopoietin |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000145777 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q969D9 |
| Gene Card | TSLP |
| Uniprot ID | Q969D9 |
| Pfam | PF15216 |
| In ASD | no |
| Allosteric Prediction | no (-0.140735408) |
| Ortholog in Animals | Alpaca_ TSLP ( ortholog_one2one ) Mouse_ Tslp ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is expressed in a number of tissues including heart, liver and prostate. Isoform 2 is the predominant form in keratinocytes of oral mucosa, skin and in salivary glands. It is secreted into saliva. {ECO:0000269|PubMed:11480573, ECO:0000269|PubMed:24850429}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5J11 (X-ray 2.56A ) 5J12 (X-ray 3.55A ) 5J13 (X-ray 2.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:11418668}. |
| Mouse PG classification | NA |
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