| Gene Information | |
|---|---|
| Gene Name | CIP2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 905 |
| Protein Names | Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000163507 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TCG1 |
| Gene Card | CIP2A |
| Uniprot ID | Q8TCG1 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.144183565) |
| Ortholog in Animals | Alpaca_ CIP2A ( ortholog_one2one ) Dog_ CIP2A ( ortholog_one2one ) GuineaPig_ CIP2A ( ortholog_one2one ) Macaque_ CIP2A ( ortholog_one2one ) Mouse_ Cip2a ( ortholog_one2one ) Pig_ CIP2A ( ortholog_one2one ) Rat_ Cip2a ( ortholog_one2one ) Rabbit_ CIP2A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCHCR1, CCDC57 |
| Tissue | NA |
| Tissue Specificity | Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). {ECO:0000269|PubMed:12118381, ECO:0000269|PubMed:17632056}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002240(Rat);0.075(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5UFL (X-ray 3.00A ) |
| DBSNP | rs7648496 rs2278911 rs9856308 rs34944683 rs13083928 rs34172460 rs6777766 rs13071874 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12118381}. Note=Slightly concentrates in the perinuclear region (PubMed:12118381). {ECO:0000269|PubMed:12118381}. |
| Mouse PG classification | NA |
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