| Gene Information | |
|---|---|
| Gene Name | SFXN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 322 |
| Protein Names | Sideroflexin-1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000164466 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H9B4 |
| Gene Card | SFXN1 |
| Uniprot ID | Q9H9B4 |
| Pfam | PF03820 |
| In ASD | no |
| Allosteric Prediction | no (-0.525778853) |
| Ortholog in Animals | Alpaca_ SFXN1 ( ortholog_one2one ) Dog_ SFXN1 ( ortholog_one2one ) GuineaPig_ SFXN1 ( ortholog_one2one ) Macaque_ SFXN1 ( ortholog_one2one ) Mouse_ Sfxn1 ( ortholog_one2one ) Pig_ SFXN1 ( ortholog_one2one ) Rat_ Sfxn1 ( ortholog_one2one ) Rabbit_ SFXN1 ( ortholog_one2one ) |
| Ohnologs | SFXN2 |
| Paralogs | SFXN3, SFXN2, SFXN4, SFXN5 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney. {ECO:0000269|PubMed:30442778}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17065105 rs34907038 |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:30442778}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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