| Gene Information | |
|---|---|
| Gene Name | HUMSIAH |
| Organism | Homo sapiens (Human) |
| Gene Length | 282 |
| Protein Names | E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8IUQ4 |
| Gene Card | SIAH1 |
| Uniprot ID | Q8IUQ4 |
| Pfam | PF03145 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed at a low level. Down-regulated in advanced hepatocellular carcinomas. {ECO:0000269|PubMed:12557228, ECO:0000269|PubMed:9403064}. |
| Pharmacological Animal Models | 0.017047(Chimpanzee);0.009861(Mouse);NULL(Rat);0.041176(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2A25 (X-ray 2.20A ) 4C9Z (X-ray 1.95A ) 4CA1 (X-ray 1.58A ) 4I7B (X-ray 3.00A ) 4I7C (X-ray 2.80A ) 4I7D (X-ray 2.40A ) 4X3G (X-ray 2.34A ) 5WZZ (X-ray 2.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. |
| Mouse PG classification | NA |
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