Gene Information
Gene NamePARP2
OrganismHomo sapiens (Human)
Gene Length583
Protein NamesPoly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)
Target Namepoly [adp-ribose] polymerase 2
Target TypeClinical trial target
Gene Age987 ( ENSG00000129484 )
Evolutionary StageEukaryota
AlphaFoldDBQ9UGN5
Gene CardPARP2
Uniprot IDQ9UGN5
PfamPF00644; PF02877; PF05406
In ASDno
Allosteric Predictionyes (0.762687853)
Ortholog in AnimalsAlpaca_ PARP2 ( ortholog_one2one )
Dog_ PARP2 ( ortholog_one2one )
GuineaPig_ PARP2 ( ortholog_one2one )
Macaque_ PARP2 ( ortholog_one2one )
Mouse_ Parp2 ( ortholog_one2one )
Pig_ PARP2 ( ortholog_one2one )
Rat_ Parp2 ( ortholog_one2one )
Rabbit_ PARP2 ( ortholog_one2one )
OhnologsNA
ParalogsPARP1, PARP3
TissueNA
Tissue SpecificityWidely expressed, mainly in actively dividing tissues (PubMed:10364231). The highest levels are in the brain, heart, pancreas, skeletal muscle and testis;
also detected in kidney, liver, lung, placenta, ovary and spleen;
levels are low in leukocytes, colon, small intestine, prostate and thymus (PubMed:10364231). {ECO:0000269|PubMed:10364231}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001445(Rat);0.028571(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3KCZ  (X-ray  2.00A  )  3KJD  (X-ray  1.95A  )  4PJV  (X-ray  2.50A  )  4TVJ  (X-ray  2.10A  )  4ZZX  (X-ray  1.65A  )  4ZZY  (X-ray  2.20A  )  5D5K  (X-ray  1.90A  )  5DSY  (X-ray  2.70A  )  6F1K  (X-ray  2.20A  )  6F5B  (X-ray  2.80A  )  6F5F  (X-ray  2.98A  )  6TX3  (X-ray  2.96A  )  6USJ  (EM  10.50A  )  6X0L  (EM  3.90A  )  6X0M  (EM  6.30A  )  6X0N  (EM  10.00A  )  7AEO  (X-ray  2.80A  ) 
DBSNP rs3093905  rs3093906  rs3093921  rs3093925  rs3093926  rs2275010 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10364231, ECO:0000269|PubMed:26704974}. Chromosome {ECO:0000269|PubMed:26704974, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:33141820, ECO:0000269|PubMed:35349716}. Note=Recruited to DNA damage sites in a PARP1-dependent process: recognizes and binds poly-ADP-ribose chains produced by PARP1 at DNA damage sites via its N-terminus, leading to its recruitment. {ECO:0000269|PubMed:26704974, ECO:0000269|PubMed:30104678, ECO:0000269|PubMed:30321391, ECO:0000269|PubMed:32939087, ECO:0000269|PubMed:33141820, ECO:0000269|PubMed:35349716}.
Mouse PG classificationNA
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