Gene Information
Gene NameNUP98
OrganismHomo sapiens (Human)
Gene Length1817
Protein NamesNuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (Nup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (Nup96)]
Target NameNA
Target TypeNA
Gene Age18 ( ENSG00000110713 )
Evolutionary StageEukaryota
AlphaFoldDBP52948
Gene CardNUP98
Uniprot IDP52948
PfamPF04096; PF12110
In ASDno
Allosteric Predictionno (-0.639336535)
Ortholog in AnimalsAlpaca_ NUP98 ( ortholog_one2one )
Dog_ NUP98 ( ortholog_one2one )
GuineaPig_ NUP98 ( ortholog_one2one )
Macaque_ NUP98 ( ortholog_one2one )
Mouse_ Nup98 ( ortholog_one2one )
Pig_ NUP98 ( ortholog_one2one )
Rat_ Nup98 ( ortholog_one2one )
Rabbit_ NUP98 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002461(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1KO6  (X-ray  3.00A  )  2Q5X  (X-ray  1.90A  )  2Q5Y  (X-ray  2.30A  )  3MMY  (X-ray  1.65A  )  4OWR  (X-ray  3.15A  )  5A9Q  (EM  23.00A  )  6BZM  (EM  0.90A  )  7PEQ  (EM  35.00A  )  7VPG  (X-ray  2.49A  )  7VPH  (X-ray  2.80A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus membrane {ECO:0000269|PubMed:10087256, ECO:0000269|PubMed:11106761, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:33360543};
Peripheral membrane protein;
Nucleoplasmic side {ECO:0000269|PubMed:11839768}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:33097660}. Nucleus, nucleoplasm {ECO:0000269|PubMed:12191480, ECO:0000269|PubMed:28221134}. Note=Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). {ECO:0000269|PubMed:11106761, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:28221134}.;
Nucleus membrane {ECO:0000269|PubMed:11106761}. Note=(Microbial infection) Remains localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000269|PubMed:11106761}.
Mouse PG classificationNA
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