| Gene Information | |
|---|---|
| Gene Name | SH3PXD2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1133 |
| Protein Names | SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000107957 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q5TCZ1 |
| Gene Card | SH3PXD2A |
| Uniprot ID | Q5TCZ1 |
| Pfam | PF00787; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.371302681) |
| Ortholog in Animals | Alpaca_ SH3PXD2A ( ortholog_one2one ) Dog_ STN1 ( ortholog_one2one ) GuineaPig_ SH3PXD2A ( ortholog_one2one ) Macaque_ SH3PXD2A ( ortholog_one2one ) Mouse_ Sh3pxd2a ( ortholog_one2one ) Pig_ SH3PXD2A ( ortholog_one2one ) Rat_ Sh3pxd2a ( ortholog_one2one ) Rabbit_ SH3PXD2A ( ortholog_one2one ) |
| Ohnologs | SH3PXD2B |
| Paralogs | NOXO1, NCF1, SH3PXD2B |
| Tissue | NA |
| Tissue Specificity | Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas. {ECO:0000269|PubMed:15710328}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DNU (NMR - ) 2EGA (NMR - ) 2EGC (NMR - ) 2EKH (NMR - ) |
| DBSNP | rs11818820 rs3781365 rs12764700 |
| Subcellular location [CC] | Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. |
| Mouse PG classification | NA |
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