| Gene Information | |
|---|---|
| Gene Name | PPIL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 520 |
| Protein Names | RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000100023 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13356 |
| Gene Card | PPIL2 |
| Uniprot ID | Q13356 |
| Pfam | PF00160 |
| In ASD | no |
| Allosteric Prediction | no (-1.183629895) |
| Ortholog in Animals | Alpaca_ PPIL2 ( ortholog_one2one ) Dog_ PPIL2 ( ortholog_one2one ) GuineaPig_ PPIL2 ( ortholog_one2one ) Macaque_ PPIL2 ( ortholog_one2one ) Mouse_ Ppil2 ( ortholog_one2one ) Pig_ PPIL2 ( ortholog_one2one ) Rat_ AABR07065010.1 ( ortholog_one2many ) Rat_ Ppil2 ( ortholog_one2many ) Rabbit_ PPIL2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PPIH, PPIL4, PPIL6, CWC27, PPIB, NKTR, PPIAL4A, PPIAL4E, PPIAL4F, PPIAL4D, PPIAL4G, PPIAL4C, PPIAL4H, PPIA, PPIC, PPIE, PPIG, PPID, PPWD1, PPIF, PPIL3, PPIL1 |
| Tissue | NA |
| Tissue Specificity | Highest expression in thymus, pancreas and testis. Also detected in heart, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, ovary, small intestine and colon. Poorly detected in brain and leukocytes. Strong protein expression in lymph node (cortical, paracortical and medullar regions), thyroid (follicular epithelial cells), testis (developing spermatozoa), stomach (cells lining the gastric pit), pancreas, kidney (proximal and distal-tubule cells and collecting duct cells but not in glomeruli), endometrium and colon (goblet cells). Moderate protein expression in spleen, prostate (epithelium and squamous cell carcinomas), placenta and adrenal gland. Weak protein expression in liver, heart, breast, ovary, and lung. No protein expression in brain and bladder. High protein expression in most lymphomas and melanomas. {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}. |
| Pharmacological Animal Models | 0.058713(Chimpanzee);0.006035(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ZKC (X-ray 1.65A ) 7ABI (EM 8.00A ) 7DVQ (EM 2.89A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}. Note=May also localize to the cytoplasm and the cell membrane. {ECO:0000269|PubMed:15946952}. |
| Mouse PG classification | NA |
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