| Gene Information | |
|---|---|
| Gene Name | LRGUK |
| Organism | Homo sapiens (Human) |
| Gene Length | 825 |
| Protein Names | Leucine-rich repeat and guanylate kinase domain-containing protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000155530 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96M69 |
| Gene Card | LRGUK |
| Uniprot ID | Q96M69 |
| Pfam | PF00625 |
| In ASD | no |
| Allosteric Prediction | no (-1.085690907) |
| Ortholog in Animals | Alpaca_ LRGUK ( ortholog_one2one ) Dog_ LRGUK ( ortholog_one2one ) GuineaPig_ LRGUK ( ortholog_one2one ) Macaque_ LRGUK ( ortholog_one2one ) Mouse_ Lrguk ( ortholog_one2one ) Pig_ LRGUK ( ortholog_one2one ) Rat_ Lrguk ( ortholog_one2one ) Rabbit_ LRGUK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LRRC43, DNAAF11, DRC3, LRRCC1, LRRC9, LRRC46, DNAAF1, LRRC49, CEP97, LRRC23, PPP1R42, LRRC61, LRRIQ3 |
| Tissue | caudate.nucleus, medulla.oblongata, pituitary.gland, testis |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17167553 rs35149449 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D5S7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9D5S7}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9D5S7}. Note=Localizes to the acrosome and acroplaxome in round spermatids. Localizes to the manchette during spermiogenesis. Also found in the basal body of elongating spermatids, and in primary cilia of somatic cells. {ECO:0000250|UniProtKB:Q9D5S7}. |
| Mouse PG classification | NA |
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