| Gene Information | |
|---|---|
| Gene Name | NCLN |
| Organism | Homo sapiens (Human) |
| Gene Length | 563 |
| Protein Names | Nicalin (Nicastrin-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000125912 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q969V3 |
| Gene Card | NCLN |
| Uniprot ID | Q969V3 |
| Pfam | PF04389 |
| In ASD | no |
| Allosteric Prediction | no (-1.435609005) |
| Ortholog in Animals | Alpaca_ NCLN ( ortholog_one2one ) Dog_ NCLN ( ortholog_one2one ) GuineaPig_ NCLN ( ortholog_one2one ) Macaque_ NCLN ( ortholog_one2one ) Mouse_ Ncln ( ortholog_one2one ) Pig_ NCLN ( ortholog_one2one ) Rat_ Ncln ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. {ECO:0000269|PubMed:15257293}. |
| Pharmacological Animal Models | 0.340275(Chimpanzee);0.020394(Mouse);0.001179(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6W6L (EM 3.84A ) |
| DBSNP | rs11671067 rs2288949 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}; Single-pass membrane protein {ECO:0000269|PubMed:15257293, ECO:0000269|PubMed:20538592}. |
| Mouse PG classification | NA |
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