| Gene Information | |
|---|---|
| Gene Name | IFNAR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 557 |
| Protein Names | Interferon alpha/beta receptor 1 (IFN-R-1) (IFN-alpha/beta receptor 1) (Cytokine receptor class-II member 1) (Cytokine receptor family 2 member 1) (CRF2-1) (Type I interferon receptor 1) |
| Target Name | interferon alpha/beta receptor 1 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000142166 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P17181 |
| Gene Card | IFNAR1 |
| Uniprot ID | P17181 |
| Pfam | PF09294; PF01108 |
| In ASD | no |
| Allosteric Prediction | yes (0.751865209) |
| Ortholog in Animals | Alpaca_ IFNAR1 ( ortholog_one2one ) Alpaca_ IFNAR1 ( ortholog_one2many ) Dog_ IFNAR1 ( ortholog_one2one ) GuineaPig_ IFNAR1 ( ortholog_one2one ) Macaque_ IFNAR1 ( ortholog_one2one ) Mouse_ Ifnar1 ( ortholog_one2one ) Pig_ IFNAR1 ( ortholog_one2one ) Rat_ Ifnar1 ( ortholog_one2one ) Rabbit_ IFNAR1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IL22RA2, IFNGR2, IL22RA1, F3, IFNLR1, IL10RA, IL20RB, IL20RA, IFNAR2, IFNGR1, IL10RB |
| Tissue | NA |
| Tissue Specificity | IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. {ECO:0000269|PubMed:8307198}. |
| Pharmacological Animal Models | 0.020968(Chimpanzee);0.021238(Mouse);0.004990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3S98 (X-ray 1.90A ) 3SE3 (X-ray 4.00A ) 3SE4 (X-ray 3.50A ) 4PO6 (X-ray 1.99A ) |
| DBSNP | rs779701967 rs201532160 rs181939581 rs1333470928 rs577823502 rs2257167 rs747690835 rs770624214 rs201281365 rs17875833 rs17875834 rs746291558 rs541858922 rs778182995 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:18056411, ECO:0000269|PubMed:2153461, ECO:0000305|PubMed:7665574}; Single-pass type I membrane protein {ECO:0000305}. Late endosome {ECO:0000269|PubMed:18056411, ECO:0000305|PubMed:14532120}. Lysosome {ECO:0000269|PubMed:18056411, ECO:0000305|PubMed:14532120}. Note=Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes. {ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:18056411}. |
| Mouse PG classification | NA |
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