| Gene Information | |
|---|---|
| Gene Name | HNF1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 631 |
| Protein Names | Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1) |
| Target Name | hepatocyte nuclear factor 1-alpha |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000135100 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P20823 |
| Gene Card | HNF1A |
| Uniprot ID | P20823 |
| Pfam | PF04814; PF04813; PF04812 |
| In ASD | no |
| Allosteric Prediction | yes (1.190095261) |
| Ortholog in Animals | Alpaca_ HNF1A ( ortholog_one2one ) Dog_ HNF1A ( ortholog_one2one ) GuineaPig_ HNF1A ( ortholog_one2one ) Macaque_ HNF1A ( ortholog_one2one ) Mouse_ Hnf1a ( ortholog_one2one ) Pig_ HNF1A ( ortholog_one2one ) Rat_ Hnf1a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HNF1B |
| Tissue | NA |
| Tissue Specificity | Liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IC8 (X-ray 2.60A ) 2GYP (X-ray 1.40A ) |
| DBSNP | rs1169288 rs1800574 rs2464196 rs1169305 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:10966642}. |
| Mouse PG classification | HPG |
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