| Gene Information | |
|---|---|
| Gene Name | DCAF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 597 |
| Protein Names | DDB1- and CUL4-associated factor 8 (WD repeat-containing protein 42A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000132716 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q5TAQ9 |
| Gene Card | DCAF8 |
| Uniprot ID | Q5TAQ9 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-1.082564287) |
| Ortholog in Animals | Alpaca_ DCAF8 ( ortholog_one2one ) Dog_ DCAF8 ( ortholog_one2one ) GuineaPig_ DCAF8 ( ortholog_one2one ) Macaque_ DCAF8 ( ortholog_one2one ) Mouse_ Dcaf8 ( ortholog_one2one ) Pig_ DCAF8 ( ortholog_one2one ) Rat_ Dcaf8 ( ortholog_one2one ) Rabbit_ DCAF8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DCAF8L2, DCAF8L1, DCAF6, WDTC1, DCAF5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3I8E (X-ray 3.40A ) |
| DBSNP | rs587777425 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:22500989}. Cytoplasm {ECO:0000269|PubMed:22500989}. Note=It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent. {ECO:0000269|PubMed:22500989}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |