| Gene Information | |
|---|---|
| Gene Name | OPRM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP) |
| Target Name | opioid receptor mu |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000112038 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35372 |
| Gene Card | OPRM1 |
| Uniprot ID | P35372 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.793417691) |
| Ortholog in Animals | Alpaca_ OPRM1 ( ortholog_one2one ) Dog_ OPRM1 ( ortholog_one2one ) GuineaPig_ OPRM1 ( ortholog_one2one ) Macaque_ OPRM1 ( ortholog_one2one ) Mouse_ Oprm1 ( ortholog_one2one ) Pig_ OPRM1 ( ortholog_one2one ) Rat_ Oprm1 ( ortholog_one2one ) Rabbit_ OPRM1 ( ortholog_one2one ) |
| Ohnologs | OPRK1, OPRL1, NPBWR2, SSTR4, SSTR1, SSTR5, OPRD1 |
| Paralogs | SSTR5, SSTR4, NPBWR1, OPRL1, GPR149, OPRK1, PTGDR2, SSTR3, CMKLR2, SSTR1, LTB4R, LTB4R2, KISS1R, UTS2R, NPBWR2, SSTR2, OPRD1 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain. Isoform 16 and isoform 17 are detected in brain. {ECO:0000269|PubMed:16580639}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1799972 rs1799971 rs9282817 rs9282819 rs17174794 rs17174801 rs1799974 rs17174822 rs17174829 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:16580639, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128}; Multi-pass membrane protein {ECO:0000269|PubMed:16580639}. Cell projection, axon {ECO:0000250|UniProtKB:P97266}. Perikaryon {ECO:0000250|UniProtKB:P97266}. Cell projection, dendrite {ECO:0000250|UniProtKB:P97266}. Endosome {ECO:0000250|UniProtKB:P97266}. Note=Is rapidly internalized after agonist binding. {ECO:0000250|UniProtKB:P97266}.; [Isoform 12]: Cytoplasm {ECO:0000269|PubMed:20525224}. |
| Mouse PG classification | NA |
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