| Gene Information | |
|---|---|
| Gene Name | OPRL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 370 |
| Protein Names | Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor) |
| Target Name | nociceptin receptor |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000125510 ) 3 ( ENSG00000277044 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P41146 |
| Gene Card | OPRL1 |
| Uniprot ID | P41146 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (0.616107562) |
| Ortholog in Animals | Alpaca_ OPRL1 ( ortholog_one2one ) GuineaPig_ OPRL1 ( ortholog_one2one ) Macaque_ OPRL1 ( ortholog_one2one ) Mouse_ Oprl1 ( ortholog_one2one ) Pig_ OPRL1 ( ortholog_one2one ) Rat_ Oprl1 ( ortholog_one2one ) |
| Ohnologs | OPRK1, OPRM1, OPRD1, SSTR1, SSTR2 |
| Paralogs | SSTR5, SSTR4, NPBWR1, GPR149, OPRM1, OPRK1, PTGDR2, SSTR3, CMKLR2, SSTR1, LTB4R, LTB4R2, KISS1R, UTS2R, NPBWR2, SSTR2, OPRD1 |
| Tissue | NA |
| Tissue Specificity | Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4EA3 (X-ray 3.01A ) 5DHG (X-ray 3.00A ) 5DHH (X-ray 3.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane. |
| Mouse PG classification | NA |
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