| Gene Information | |
|---|---|
| Gene Name | MAP4K2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 820 |
| Protein Names | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) |
| Target Name | mitogen-activated protein kinase kinase kinase kinase 2 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000168067 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q12851 |
| Gene Card | MAP4K2 |
| Uniprot ID | Q12851 |
| Pfam | PF00780; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.807826548) |
| Ortholog in Animals | Alpaca_ MAP4K2 ( ortholog_one2one ) Dog_ MAP4K2 ( ortholog_one2one ) GuineaPig_ MAP4K2 ( ortholog_one2one ) Macaque_ MAP4K2 ( ortholog_one2one ) Mouse_ Map4k2 ( ortholog_one2one ) Pig_ MAP4K2 ( ortholog_one2one ) Rat_ Map4k2 ( ortholog_one2one ) |
| Ohnologs | MAP4K5, MAP4K1, MAP4K3 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. {ECO:0000269|PubMed:7515885}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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