| Gene Information | |
|---|---|
| Gene Name | ARIH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 493 |
| Protein Names | E3 ubiquitin-protein ligase ARIH2 (ARI-2) (Protein ariadne-2 homolog) (EC 2.3.2.31) (RING-type E3 ubiquitin transferase ARIH2) (Triad1 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000177479 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95376 |
| Gene Card | ARIH2 |
| Uniprot ID | O95376 |
| Pfam | PF19422; PF01485 |
| In ASD | no |
| Allosteric Prediction | no (-0.135803866) |
| Ortholog in Animals | Alpaca_ ARIH2 ( ortholog_one2one ) Dog_ ARIH2 ( ortholog_one2one ) GuineaPig_ ARIH2 ( ortholog_one2one ) Macaque_ ARIH2 ( ortholog_one2one ) Mouse_ Arih2 ( ortholog_one2one ) Pig_ ARIH2 ( ortholog_one2one ) Rat_ Arih2 ( ortholog_one2one ) Rabbit_ ARIH2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF19A, RNF144A, RNF217, PRKN, RNF14, ARIH1, ANKIB1, RNF144B, RNF19B |
| Tissue | NA |
| Tissue Specificity | Widely expressed with higher expression in granulocytes. {ECO:0000269|PubMed:16118314}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.015385(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7OD1 (X-ray 2.45A ) 7ONI (EM 3.40A ) |
| DBSNP | rs11507 rs34221642 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16118314}. Cytoplasm {ECO:0000269|PubMed:19340006}. |
| Mouse PG classification | NA |
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