| Gene Information | |
|---|---|
| Gene Name | CIDEA |
| Organism | Homo sapiens (Human) |
| Gene Length | 219 |
| Protein Names | Cell death activator CIDE-A (Cell death-inducing DFFA-like effector A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000176194 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O60543 |
| Gene Card | CIDEA |
| Uniprot ID | O60543 |
| Pfam | PF02017 |
| In ASD | no |
| Allosteric Prediction | no (-0.38123924) |
| Ortholog in Animals | Alpaca_ CIDEA ( ortholog_one2one ) Dog_ CIDEA ( ortholog_one2one ) GuineaPig_ CIDEA ( ortholog_one2one ) Macaque_ CIDEA ( ortholog_one2one ) Mouse_ Cidea ( ortholog_one2one ) Pig_ CIDEA ( ortholog_one2one ) Rat_ Cidea ( ortholog_one2one ) Rabbit_ CIDEA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CIDEC, CIDEB, DFFA |
| Tissue | adipose.tissue, bone.marrow, breast, pulmonary.valve, greater.omentum, subcutaneous.adipose.tissue |
| Tissue Specificity | Expressed in omental and subcutaneous adipose tissue (at protein level). {ECO:0000269|PubMed:18509062}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EEL (NMR - ) |
| DBSNP | rs11545881 |
| Subcellular location [CC] | Lipid droplet {ECO:0000269|PubMed:18509062}. Nucleus {ECO:0000250}. Note=Enriched at lipid droplet contact sites. Has been shown to localize to mitochondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062). {ECO:0000250, ECO:0000269|PubMed:18509062}. |
| Mouse PG classification | NA |
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