| Gene Information | |
|---|---|
| Gene Name | OPGL |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O14788 |
| Gene Card | TNFSF11 |
| Uniprot ID | O14788 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. |
| Pharmacological Animal Models | 0.087880(Chimpanzee);0.088150(Mouse);NULL(Rat);0.133333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3URF (X-ray 2.70A ) 5BNQ (X-ray 2.80A ) |
| DBSNP | rs121909072 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cytoplasm {ECO:0000250}.; [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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