Gene Information
Gene NameNDST1
OrganismHomo sapiens (Human)
Gene Length882
Protein NamesBifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.5.1.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.8)]
Target Namebifunctional heparan sulfate n-deacetylase/n-sulfotransferase 1
Target TypeNA
Gene Age987 ( ENSG00000070614 )
Evolutionary StageVertebrata
AlphaFoldDBP52848
Gene CardNDST1
Uniprot IDP52848
PfamPF12062; PF00685
In ASDyes
Allosteric Predictionno (-0.607990169)
Ortholog in AnimalsAlpaca_ NDST1 ( ortholog_one2one )
Dog_ NDST1 ( ortholog_one2one )
GuineaPig_ NDST1 ( ortholog_one2one )
Mouse_ Ndst1 ( ortholog_one2one )
Pig_ NDST1 ( ortholog_one2one )
Rat_ Ndst1 ( ortholog_one2one )
Rabbit_ NDST1 ( ortholog_one2one )
OhnologsNDST2, NDST4, NDST3
ParalogsHS3ST3A1, HS3ST1, HS3ST4, HS3ST2, NDST3, HS3ST6, NDST4, NDST2, HS3ST3B1, HS3ST5
TissueNA
Tissue SpecificityWidely expressed. Expression is most abundant in heart, liver and pancreas. {ECO:0000269|PubMed:9230113}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1NST  (X-ray  2.30A  ) 
DBSNP rs606231459  rs606231458  rs606231457  rs606231456 
Subcellular location [CC][Isoform 1]: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:9230113};
Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078};
Single-pass type II membrane protein {ECO:0000255}.;
[Isoform 3]: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:35137078};
Single-pass type II membrane protein {ECO:0000255}.
Mouse PG classificationLPG
click here to return to the previous page