| Gene Information | |
|---|---|
| Gene Name | OMI |
| Organism | Homo sapiens (Human) |
| Gene Length | 458 |
| Protein Names | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O43464 |
| Gene Card | HTRA2 |
| Uniprot ID | O43464 |
| Pfam | PF17820; PF02163 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Ubiquitously expressed. {ECO:0000269|PubMed:10644717}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LCY (X-ray 2.00A ) 2PZD (X-ray 2.75A ) 5FHT (X-ray 1.95A ) 5M3N (X-ray 1.65A ) 5M3O (X-ray 1.70A ) 5TNY (X-ray 1.70A ) 5TNZ (X-ray 1.75A ) 5TO0 (X-ray 1.90A ) 5TO1 (X-ray 1.69A ) 5WYN (X-ray 2.05A ) 7VGE (X-ray 4.00A ) |
| DBSNP | rs775840965 rs150047108 rs757704467 rs72470544 rs375322953 rs1057519082 rs72470545 rs767006508 rs1380794702 |
| Subcellular location [CC] | Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.; [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:10644717}. |
| Mouse PG classification | NA |
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