| Gene Information | |
|---|---|
| Gene Name | OLIG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 323 |
| Protein Names | Oligodendrocyte transcription factor 2 (Oligo2) (Class B basic helix-loop-helix protein 1) (bHLHb1) (Class E basic helix-loop-helix protein 19) (bHLHe19) (Protein kinase C-binding protein 2) (Protein kinase C-binding protein RACK17) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000205927 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q13516 |
| Gene Card | OLIG2 |
| Uniprot ID | Q13516 |
| Pfam | PF00010 |
| In ASD | no |
| Allosteric Prediction | no (-1.28049091) |
| Ortholog in Animals | Dog_ OLIG2 ( ortholog_one2one ) GuineaPig_ OLIG2 ( ortholog_one2one ) Macaque_ OLIG2 ( ortholog_one2one ) Mouse_ Olig2 ( ortholog_one2one ) Pig_ OLIG2 ( ortholog_one2one ) Rat_ Olig2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BHLHE23, BHLHA15, NEUROD6, NEUROG1, ATOH1, ATOH7, NEUROG2, BHLHE22, NEUROD4, ATOH8, OLIG3, NEUROD1, NEUROG3, OLIG1, NEUROD2 |
| Tissue | brain, cerebral.cortex, amygdala, caudate.nucleus, hippocampus, hypothalamus, nucleus.accumbens, putamen, substantia.nigra |
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. {ECO:0000269|PubMed:11498220, ECO:0000269|PubMed:11526205}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Cytoplasm {ECO:0000250}. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}. |
| Mouse PG classification | NA |
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