| Gene Information | |
|---|---|
| Gene Name | CLIC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 410 |
| Protein Names | Chloride intracellular channel protein 5 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000112782 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NZA1 |
| Gene Card | CLIC5 |
| Uniprot ID | Q9NZA1 |
| Pfam | PF13409 |
| In ASD | no |
| Allosteric Prediction | no (-0.35800616) |
| Ortholog in Animals | Alpaca_ CLIC5 ( ortholog_one2one ) Dog_ CLIC5 ( ortholog_one2one ) GuineaPig_ CLIC5 ( ortholog_one2one ) Macaque_ CLIC5 ( ortholog_one2one ) Mouse_ Clic5 ( ortholog_one2one ) Pig_ CLIC5 ( ortholog_one2one ) Rat_ Clic5 ( ortholog_one2one ) Rabbit_ CLIC5 ( ortholog_one2one ) |
| Ohnologs | CLIC6, CLIC4 |
| Paralogs | CLIC2, GSTZ1, GSTO2, GDAP1L1, CLIC3, GSTT4, CLIC4, GSTT2, GSTT2B, CLIC1, EEF1G, GDAP1, GSTO1, CLIC6 |
| Tissue | artery, heart, left.atrium, left.ventricle, mitral.valve, penis, pulmonary.valve, tongue, tricuspid.valve, atrium, lung, skeletal.muscle |
| Tissue Specificity | Widely expressed in both fetal and adult human tissues (PubMed:24781754). Isoform 1 is expressed in renal glomeruli endothelial cells and podocytes (at protein level). {ECO:0000269|PubMed:20335315, ECO:0000269|PubMed:24781754}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6Y2H (X-ray 2.15A ) |
| DBSNP | rs723580 rs35822882 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:15184393}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15184393}. Membrane {ECO:0000269|PubMed:15184393, ECO:0000305|PubMed:18028448}; Single-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:20335315}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O00299}. Note=Associates with the cortical actin cytoskeleton (PubMed:10793131, PubMed:15184393). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (By similarity). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (PubMed:20335315). May localize to the centrosome in lens epithelial cells (By similarity). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250|UniProtKB:O00299, ECO:0000250|UniProtKB:Q8BXK9, ECO:0000250|UniProtKB:Q9EPT8, ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:15184393, ECO:0000269|PubMed:20335315}.; [Isoform 2]: Golgi apparatus {ECO:0000269|PubMed:12163479}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12163479}. Note=Colocalizes with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome. {ECO:0000269|PubMed:12163479}. |
| Mouse PG classification | HPG |
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