| Gene Information | |
|---|---|
| Gene Name | DUSP18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 188 |
| Protein Names | Dual specificity protein phosphatase 18 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 20) (LMW-DSP20) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 18 ( ENSG00000167065 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NEJ0 |
| Gene Card | DUSP18 |
| Uniprot ID | Q8NEJ0 |
| Pfam | PF00782 |
| In ASD | no |
| Allosteric Prediction | no (-1.006298793) |
| Ortholog in Animals | Alpaca_ DUSP18 ( ortholog_one2one ) Dog_ DUSP18 ( ortholog_one2one ) GuineaPig_ DUSP18 ( ortholog_one2one ) Macaque_ DUSP18 ( ortholog_one2one ) Mouse_ Dusp18 ( ortholog_one2one ) Pig_ DUSP18 ( ortholog_one2one ) Rat_ Dusp18 ( ortholog_one2one ) Rabbit_ DUSP18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DUSP6, DUSP4, DUSP12, DUSP10, STYXL2, SSH3, DUSP19, DUSP1, KASH5, SSH1, DUSP29, DUSP16, DUSP21, DUSP2, DUSP8, DUSP13, EPM2A, DUSP7, DUSP26, STYX, SSH2, PTPMT1, DUSP22, DUSP15, DUSP14, DUSP28, STYXL1, DUSP5, DUSP9, DUSP3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in liver, brain, ovary and testis. {ECO:0000269|PubMed:12408986, ECO:0000269|PubMed:12591617}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ESB (X-ray 2.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12408986}. Nucleus {ECO:0000269|PubMed:12408986}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VE01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VE01}; Intermembrane side {ECO:0000250|UniProtKB:Q8VE01}. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250|UniProtKB:Q8VE01}. |
| Mouse PG classification | NA |
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