| Gene Information | |
|---|---|
| Gene Name | TET3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1795 |
| Protein Names | Methylcytosine dioxygenase TET3 (EC 1.14.11.n2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000187605 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O43151 |
| Gene Card | TET3 |
| Uniprot ID | O43151 |
| Pfam | PF12851; PF02008 |
| In ASD | no |
| Allosteric Prediction | no (-0.990286789) |
| Ortholog in Animals | Alpaca_ TET3 ( ortholog_one2one ) Dog_ TET3 ( ortholog_one2one ) GuineaPig_ TET3 ( ortholog_one2one ) Macaque_ TET3 ( ortholog_one2one ) Mouse_ Tet3 ( ortholog_one2one ) Pig_ TET3 ( ortholog_one2one ) Rat_ Tet3 ( ortholog_one2one ) Rabbit_ TET3 ( ortholog_one2one ) |
| Ohnologs | TET1 |
| Paralogs | TET1, TET2 |
| Tissue | NA |
| Tissue Specificity | Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes. {ECO:0000269|PubMed:12646957}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Z3C (X-ray 1.57A ) |
| DBSNP | rs57955681 rs534089911 rs1573856970 rs1227643933 rs1573906351 rs1573906389 rs1174857008 rs1691236972 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q8BG87}. Cytoplasm {ECO:0000250|UniProtKB:Q8BG87}. Chromosome {ECO:0000250|UniProtKB:Q8BG87}. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. Binds to the promoter of target genes, close to the transcription start site. {ECO:0000250|UniProtKB:Q8BG87}. |
| Mouse PG classification | NA |
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