| Gene Information | |
|---|---|
| Gene Name | OIT3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 545 |
| Protein Names | Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000138315 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8WWZ8 |
| Gene Card | OIT3 |
| Uniprot ID | Q8WWZ8 |
| Pfam | PF00100 |
| In ASD | no |
| Allosteric Prediction | no (-1.373925098) |
| Ortholog in Animals | Alpaca_ OIT3 ( ortholog_one2one ) Dog_ OIT3 ( ortholog_one2one ) GuineaPig_ OIT3 ( ortholog_one2one ) Macaque_ OIT3 ( ortholog_one2one ) Mouse_ Oit3 ( ortholog_one2one ) Pig_ OIT3 ( ortholog_one2one ) Rat_ Oit3 ( ortholog_one2one ) Rabbit_ OIT3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GP2, ZPLD1, TECTB, UMODL1, UMOD |
| Tissue | liver |
| Tissue Specificity | Liver-specific. Expressed only in the hepatocytes. Down-regulated in hepatocellular carcinoma (HCC) and HCC cell lines. {ECO:0000269|PubMed:12939600}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35089256 |
| Subcellular location [CC] | Nucleus envelope {ECO:0000269|PubMed:12939600}. Note=Can be secreted into blood. |
| Mouse PG classification | NA |
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