| Gene Information | |
|---|---|
| Gene Name | ARHGAP45 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1136 |
| Protein Names | Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000180448 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q92619 |
| Gene Card | ARHGAP45 |
| Uniprot ID | Q92619 |
| Pfam | PF00620 |
| In ASD | no |
| Allosteric Prediction | no (-0.166816034) |
| Ortholog in Animals | Alpaca_ ARHGAP45 ( ortholog_one2one ) Dog_ ARHGAP45 ( ortholog_one2one ) Macaque_ ARHGAP45 ( ortholog_one2one ) Mouse_ Arhgap45 ( ortholog_one2one ) Pig_ ARHGAP45 ( ortholog_one2one ) Rat_ Arhgap45 ( ortholog_one2one ) |
| Ohnologs | GMIP, ARHGAP29 |
| Paralogs | GMIP, ARHGAP29 |
| Tissue | spleen |
| Tissue Specificity | Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue. {ECO:0000269|PubMed:11965046, ECO:0000269|PubMed:8843592}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3D25 (X-ray 1.30A ) 3FT3 (X-ray 1.95A ) |
| DBSNP | rs1801284 rs2074442 rs7251797 rs36084354 rs34569196 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:24086303}. Cell projection, ruffle membrane {ECO:0000269|PubMed:24086303}. |
| Mouse PG classification | NA |
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