| Gene Information | |
|---|---|
| Gene Name | OGT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1046 |
| Protein Names | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000147162 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O15294 |
| Gene Card | OGT |
| Uniprot ID | O15294 |
| Pfam | PF13844; PF00515; PF13181 |
| In ASD | no |
| Allosteric Prediction | yes (0.359697575) |
| Ortholog in Animals | Alpaca_ OGT ( ortholog_one2one ) Dog_ OGT ( ortholog_one2one ) GuineaPig_ OGT ( ortholog_one2one ) Macaque_ OGT ( ortholog_one2one ) Mouse_ Ogt ( ortholog_one2one ) Pig_ OGT ( ortholog_one2one ) Rat_ Ogt ( ortholog_one2one ) Rabbit_ OGT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BBS4, CFAP70, TTC34, TTC6, TMTC1, TTC16, TMTC4, TTC13, TTC7A, TMTC2, TMTC3, TTC8, IFT88, TTC7B |
| Tissue | NA |
| Tissue Specificity | Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver. {ECO:0000269|PubMed:9083068}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1W3B (X-ray 2.85A ) 3PE3 (X-ray 2.78A ) 3PE4 (X-ray 1.95A ) 3TAX (X-ray 1.88A ) 4AY5 (X-ray 3.15A ) 4AY6 (X-ray 3.30A ) 4CDR (X-ray 3.15A ) 4GYW (X-ray 1.70A ) 4GYY (X-ray 1.85A ) 4GZ3 (X-ray 1.90A ) 4GZ5 (X-ray 3.08A ) 4GZ6 (X-ray 2.98A ) 4N39 (X-ray 1.76A ) 4N3A (X-ray 1.88A ) 4N3B (X-ray 2.17A ) 4N3C (X-ray 2.55A ) 4XI9 (X-ray 3.10A ) 4XIF (X-ray 3.20A ) 5BNW (X-ray 2.40A ) 5C1D (X-ray 2.05A ) 5HGV (X-ray 2.05A ) 5LVV (X-ray 2.54A ) 5LWV (X-ray 1.90A ) 5NPR (X-ray 1.85A ) 5NPS (X-ray 1.68A ) 5VIE (X-ray 2.60A ) 5VIF (X-ray 2.25A ) 6E37 (X-ray 2.53A ) 6EOU (X-ray 1.75A ) 6IBO (X-ray 2.17A ) 6MA1 (X-ray 2.75A ) 6MA2 (X-ray 2.10A ) 6MA3 (X-ray 2.00A ) 6MA4 (X-ray 2.00A ) 6MA5 (X-ray 2.00A ) 6Q4M (X-ray 2.20A ) 6TKA (X-ray 1.91A ) 7NTF (EM 5.32A ) |
| DBSNP | rs1131692155 rs1114167891 rs1602147851 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:26678539}. Cytoplasm {ECO:0000269|PubMed:26678539}. Note=Predominantly localizes to the nucleus. {ECO:0000269|PubMed:26678539}.; [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:20824293}. Membrane {ECO:0000269|PubMed:20824293}. Note=Associates with the mitochondrial inner membrane. {ECO:0000269|PubMed:20824293}.; [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:21285374}. Nucleus {ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:21285374}. Cell membrane {ECO:0000250|UniProtKB:P56558}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56558}. Cell projection {ECO:0000250|UniProtKB:P56558}. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By similarity). {ECO:0000250|UniProtKB:P56558, ECO:0000269|PubMed:21285374}.; [Isoform 4]: Cytoplasm. Nucleus. |
| Mouse PG classification | NA |
| click here to return to the previous page | |