| Gene Information | |
|---|---|
| Gene Name | IL1RAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 570 |
| Protein Names | Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (EC 3.2.2.6) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000196083 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPH3 |
| Gene Card | IL1RAP |
| Uniprot ID | Q9NPH3 |
| Pfam | PF18452; PF01582 |
| In ASD | no |
| Allosteric Prediction | no (-0.153441166) |
| Ortholog in Animals | Alpaca_ IL1RAP ( ortholog_one2one ) Dog_ IL1RAP ( ortholog_one2one ) GuineaPig_ IL1RAP ( ortholog_one2one ) Macaque_ IL1RAP ( ortholog_one2one ) Mouse_ Il1rap ( ortholog_one2one ) Pig_ IL1RAP ( ortholog_one2one ) Rat_ Il1rap ( ortholog_one2one ) Rabbit_ IL1RAP ( ortholog_one2one ) |
| Ohnologs | IL1RAPL1, IL1RAPL2, IL1RL1, IL18R1, IL18RAP |
| Paralogs | IL1R1, LAG3, IL18R1, IL1R2, IL1RL1, IL1RL2, IL18RAP, SIGIRR, IL1RAPL2, IL1RAPL1 |
| Tissue | liver |
| Tissue Specificity | Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850). {ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:19481478, ECO:0000269|PubMed:20805474, ECO:0000269|PubMed:22723552, ECO:0000269|PubMed:23479569, ECO:0000269|PubMed:25595648}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3O4O (X-ray 3.30A ) 4DEP (X-ray 3.10A ) 7FCC (X-ray 2.14A ) |
| DBSNP | rs34661910 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted. |
| Mouse PG classification | NA |
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