| Gene Information | |
|---|---|
| Gene Name | OGG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 345 |
| Protein Names | N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000114026 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O15527 |
| Gene Card | OGG1 |
| Uniprot ID | O15527 |
| Pfam | PF00730; PF07934 |
| In ASD | no |
| Allosteric Prediction | yes (0.836867074) |
| Ortholog in Animals | Alpaca_ OGG1 ( ortholog_one2one ) Dog_ OGG1 ( ortholog_one2one ) GuineaPig_ OGG1 ( ortholog_one2one ) Macaque_ OGG1 ( ortholog_one2one ) Mouse_ Ogg1 ( ortholog_one2one ) Rat_ Ogg1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EBM (X-ray 2.10A ) 1FN7 (X-ray 2.60A ) 1HU0 (X-ray 2.35A ) 1KO9 (X-ray 2.15A ) 1LWV (X-ray 2.30A ) 1LWW (X-ray 2.10A ) 1LWY (X-ray 2.01A ) 1M3H (X-ray 2.05A ) 1M3Q (X-ray 1.90A ) 1N39 (X-ray 2.20A ) 1N3A (X-ray 2.20A ) 1N3C (X-ray 2.70A ) 1YQK (X-ray 2.50A ) 1YQL (X-ray 2.60A ) 1YQM (X-ray 2.50A ) 1YQR (X-ray 2.43A ) 2I5W (X-ray 2.60A ) 2NOB (X-ray 2.10A ) 2NOE (X-ray 2.20A ) 2NOF (X-ray 2.35A ) 2NOH (X-ray 2.01A ) 2NOI (X-ray 2.35A ) 2NOL (X-ray 2.57A ) 2NOZ (X-ray 2.43A ) 2XHI (X-ray 1.55A ) 3IH7 (X-ray 3.10A ) 3KTU (X-ray 2.30A ) 5AN4 (X-ray 1.60A ) 6RLW (X-ray 2.00A ) 6W0M (X-ray 2.37A ) 6W0R (X-ray 2.35A ) 6W13 (X-ray 2.38A ) 7AYY (X-ray 2.00A ) |
| DBSNP | rs772520254 rs104893751 rs17050550 rs747638147 rs56053615 rs1805373 rs3219012 rs1801128 rs3219014 rs1052133 |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000269|PubMed:17148573}. Nucleus speckle {ECO:0000269|PubMed:17148573}. Nucleus matrix {ECO:0000269|PubMed:17148573}. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.; [Isoform 1A]: Nucleus.; [Isoform 2A]: Mitochondrion. |
| Mouse PG classification | NA |
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