Gene Information
Gene NamePRMT1
OrganismHomo sapiens (Human)
Gene Length371
Protein NamesProtein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4)
Target Nameprotein arginine n-methyltransferase 1
Target TypeNA
Gene Age680 ( ENSG00000126457 )
Evolutionary StageEukaryota
AlphaFoldDBQ99873
Gene CardPRMT1
Uniprot IDQ99873
PfamPF13649
In ASDyes
Allosteric Predictionyes (1.035168499)
Ortholog in AnimalsAlpaca_ PRMT1 ( ortholog_one2one )
Dog_ PRMT1 ( ortholog_one2one )
GuineaPig_ PRMT1 ( ortholog_one2one )
Macaque_ PRMT1 ( ortholog_one2one )
Mouse_ Prmt1 ( ortholog_one2one )
Pig_ PRMT1 ( ortholog_one2one )
Rat_ Prmt1 ( ortholog_one2many )
Rabbit_ PRMT1 ( ortholog_one2one )
OhnologsPRMT8
ParalogsPRMT2, PRMT7, PRMT9, CARM1, PRMT6, PRMT3, PRMT8
Tissuepineal.gland
Tissue SpecificityWidely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436). {ECO:0000269|PubMed:11097842, ECO:0000269|PubMed:28040436}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.034286(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6NT2  (X-ray  2.48A  ) 
DBSNP rs1804486  rs11673683 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10749851, ECO:0000269|PubMed:11387442, ECO:0000269|PubMed:16879614}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9JIF0}. Cytoplasm {ECO:0000269|PubMed:26876602}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JIF0}. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity). {ECO:0000250|UniProtKB:Q9JIF0}.
Mouse PG classificationNA
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