| Gene Information | |
|---|---|
| Gene Name | PALLD |
| Organism | Homo sapiens (Human) |
| Gene Length | 1383 |
| Protein Names | Palladin (SIH002) (Sarcoma antigen NY-SAR-77) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000129116 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8WX93 |
| Gene Card | PALLD |
| Uniprot ID | Q8WX93 |
| Pfam | PF07679 |
| In ASD | no |
| Allosteric Prediction | no (-0.918585311) |
| Ortholog in Animals | Alpaca_ PALLD ( ortholog_one2one ) Dog_ PALLD ( ortholog_one2one ) GuineaPig_ PALLD ( ortholog_one2one ) Macaque_ PALLD ( ortholog_one2one ) Mouse_ Palld ( ortholog_one2one ) Pig_ PALLD ( ortholog_one2one ) Rat_ Palldl1 ( ortholog_one2one ) Rabbit_ PALLD ( ortholog_one2one ) |
| Ohnologs | MYPN |
| Paralogs | MYPN, OBSCN, HMCN1, IGFN1, CCDC141, ALPK3, SPEG, SPEGNB, MYOT |
| Tissue | NA |
| Tissue Specificity | Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines. {ECO:0000269|PubMed:11598191}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DM2 (NMR - ) 2DM3 (NMR - ) |
| DBSNP | rs7671781 rs7655494 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}. Cell junction, focal adhesion {ECO:0000269|PubMed:17322171}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:16125169}. Cell projection, ruffle {ECO:0000269|PubMed:17537434}. Cell projection, podosome {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, lamellipodium {ECO:0000269|PubMed:17537434}. Cell projection, axon {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, growth cone {ECO:0000250|UniProtKB:P0C5E3}. Note=Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434). Preferentially expressed in the excitatory presynaptic terminals (By similarity). {ECO:0000250|UniProtKB:P0C5E3, ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}. |
| Mouse PG classification | NA |
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