| Gene Information | |
|---|---|
| Gene Name | OCTN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 557 |
| Protein Names | Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | O76082 |
| Gene Card | SLC22A5 |
| Uniprot ID | O76082 |
| Pfam | PF00083 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Strongly expressed in kidney, skeletal muscle, heart and placenta (PubMed:10454528). Primarily expressed by surface epithelial cells of the colon (at protein level) (PubMed:18005709). Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells (PubMed:10454528). {ECO:0000269|PubMed:10454528, ECO:0000269|PubMed:18005709}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs139203363 rs267607052 rs11568520 rs72552723 rs144020613 rs772578415 rs72552724 rs72552725 rs199689597 rs377767445 rs202088921 rs757711838 rs72552726 rs386134190 rs386134191 rs377767450 rs386134192 rs201082652 rs748605096 rs151231558 rs1178584184 rs10040427 rs386134193 rs121908889 rs121908890 rs781721860 rs145068530 rs386134196 rs386134197 rs796052033 rs386134198 rs121908888 rs386134199 rs386134205 rs185551386 rs756650860 rs386134206 rs114269482 rs1457258524 rs72552728 rs200699819 rs386134203 rs201262157 rs201262157 rs386134208 rs386134210 rs386134211 rs72552729 rs1554087707 rs72552730 rs77300588 rs774792831 rs150544263 rs68018207 rs1385634398 rs61731073 rs886042092 rs386134214 rs144547521 rs121908891 rs267607054 rs72552732 rs267607053 rs72552733 rs386134218 rs386134219 rs11568514 rs72552734 rs1408166345 rs60376624 rs386134221 rs386134222 rs749282641 rs386134223 rs72552735 rs11568513 rs11568513 rs377216516 rs28383481 rs1157198543 rs11568521 rs11568524 rs11568525 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10679939, ECO:0000269|PubMed:17509700, ECO:0000269|PubMed:33334877}; Multi-pass membrane protein {ECO:0000269|PubMed:10679939}. Apical cell membrane {ECO:0000269|PubMed:10966938, ECO:0000269|PubMed:20722056}; Multi-pass membrane protein {ECO:0000255}. Note=In intestinal cells, apical expression is induced by TNF. {ECO:0000269|PubMed:20722056}.; [Isoform 3]: Endoplasmic reticulum {ECO:0000269|PubMed:17509700}. |
| Mouse PG classification | NA |
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