| Gene Information | |
|---|---|
| Gene Name | SLC6A9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9) |
| Target Name | glycine transporter glyt-1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000196517 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P48067 |
| Gene Card | SLC6A9 |
| Uniprot ID | P48067 |
| Pfam | PF00209 |
| In ASD | no |
| Allosteric Prediction | no (-0.557320692) |
| Ortholog in Animals | Alpaca_ SLC6A9 ( ortholog_one2one ) Dog_ SLC6A9 ( ortholog_one2one ) GuineaPig_ SLC6A9 ( ortholog_one2one ) Macaque_ SLC6A9 ( ortholog_one2one ) Mouse_ Slc6a9 ( ortholog_one2one ) Pig_ SLC6A9 ( ortholog_one2one ) Rat_ Slc6a9 ( ortholog_one2one ) Rabbit_ SLC6A9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC6A20, SLC6A2, SLC6A18, SLC6A7, SLC6A4, SLC6A16, SLC6A8, SLC6A5, SLC6A14, SLC6A6, SLC6A15, SLC6A13, SLC6A11, SLC6A19, SLC6A1, SLC6A17, SLC6A12, SLC6A3 |
| Tissue | adrenal.gland |
| Tissue Specificity | [Isoform GlyT-1A]: Expressed in the brain, kidney, pancreas, lung, placenta and liver. {ECO:0000269|PubMed:8183239}.; [Isoform GlyT-1B]: Expressed in the brain, kidney, pancreas, lung, placenta and liver. {ECO:0000269|PubMed:8183239}.; [Isoform GlyT-1C]: Expressed only in the brain. {ECO:0000269|PubMed:8183239}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6ZBV (X-ray 3.40A ) 6ZPL (X-ray 3.94A ) |
| DBSNP | rs1057519313 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P28572}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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